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KMID : 0617219910020010075
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Duksung Bulletin Phamaceutical Sciences
1991 Volume.2 No. 1 p.75 ~ p.83
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Microcirculatory Aberrations in the Isolated Perfused Pat Liver Induced by Sodium Cyanide, Anoxia or Acetaminophen
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Jung Kihwa
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Abstract
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When acetaminophen (25mM) was introduced into the perfused rat liver, the hepatic O_2 uptake was rapidly inhibited first and then later slow-down. The rapid inhibition was found to be due to mitochondrial blokade, whereas the so-called "slow inhibition" was associated with microcirculatory aberrations as evidenced by inhomogeneous staining of the liver tissue by trypan blue infusion(0.1％). NaCN(0.5mM) also caused rapid and slow respiratory inhibitions, giving heterogeneous trypan blue staining. Similarly inhomogeneous trypan blue staining was noted when the liver was perfused with anoxic medium. Accompanying the slow inhibition and heterogeneous trypan blue staining appeared to be a release of lactate dehydrogenase from the liver into the effluent.
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